Pharmaceutical Granulation And Compression

Description

Granulation and compression are two very important processes that are carried out extensively by most pharmaceutical companies. However, the theory of granulation is little understood and the selection of a particular machine and granulation method, is often done on the basis of tradition, rather than by using strict scientific or cost-benefit criteria. The basic techniques have changed dramatically in recent years and granulation for controlled release, extrusion, spheronisation, fluidization techniques, spray drying, melt extrusion, oral dispersion technology and roller compaction are new technologies that are increasingly being used in modern pharmaceutical production, which exhibit many advantages over previously available techniques. As with granulation, compression is also little understood and why some materials/formulations will compress well whilst others compact with difficulty, is slowly being elucidated. The Course will examine current granulation and compression theory and practice. Emphasis will be made as to how this theory and practice relates to current pharmaceutical development and production, with special reference to the machinery used. Scale-Up, Transfer Technology and SUPAC will also be addressed. A particular feature of the Course will be the workshop on new melt extrusion technology.

Objectives
The aims of the Course are to provide a comprehensive and sound understanding of the theory and practice of tablet granulation and compression and to appreciate the various processes batch or continuous, that are available. The importance of the granulation process in producing good quality tablets will be emphasized. The modern techniques of extrusion, spheronisation, powder layering, roller compaction, fluid-bed processing, spray drying, melt extrusion, oral dispersion technology and tablet compression will be covered. The Course will be taught primarily by industrial scientists who have been closely involved with investigating these granulation and compression processes and thus a pragmatic approach will be adopted throughout.

Outline
1. Methods and Reasons for Granulating
2. Excipients
3. Properties of Granules
4. Granulation for Controlled Release
5. High Speed Granulation and End-Point Control
6. Integrated Mixer-Granulator Dryers
7. Fluid Bed Granulation
8. Layering
9. Spray Drying
10. Pellet Manufacture
11. Extrusion and Spheronization
12. Hot Melt Extrusion
13. Roller Compaction
14. Compression Theory
15. Compression Machinery
16. Compaction Simulators
17. Tabletting and Tooling Problems
18. Oral Dispersion Tabletting Technology
19. Scale-Up, Transfer Technology and Supac

Participants
All who are working in pharmaceutical research, formulation, development, production, QA/QC and registration who require a sound understanding of the various granulation and compression methods and who wish to appreciate some of the advantages of the newer methods of granulation, spheronisation, roller compaction, layering, melt extrusion and compression that are now available.

Venue
Bandung / Yogyakarta / Bali
In House Training:
Depend on request
“if there is demand for the implementation of training in another city we are ready to serve”

Instructor
Ir. Chandra Wahyu Purnomo

Course Fee
Biaya pelatihan sebesar Rp 7.000.000/peserta Non residensial. Khusus untuk pengiriman 3 peserta dari perusahaan yang sama, biaya pendaftaran sebesar Rp.6.500.000

Facilities

• Training Module
• Flash Disk contains training material
• Certificate
• Stationeries: NoteBook and Ballpoint
• Backpack
• Training Photo
• Training room with Full AC facilities and multimedia
• Lunch and twice coffeebreak every day of training
• Qualified Instructor
• Exclusive Gifts
• Transportation for participants from hotel of participants to/from hotel of training (if minimal participants is 4 persons from the same company)

(pc)